Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana
Identifieur interne : 000114 ( France/Analysis ); précédent : 000113; suivant : 000115Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana
Auteurs : Emilie Faway [Belgique] ; Lise Musset ; Stéphane Pelleau ; Béatrice Volney ; Jessica Casteras ; Valérie Caro [France] ; Didier Menard [Cambodge] ; Sébastien Briolant [France] ; Eric LegrandSource :
- Malaria Journal [ 1475-2875 ] ; 2016-11-08.
Abstract
BACKGROUND:Plasmodium vivax malaria is a major public health problem in French Guiana. Some cases of resistance to chloroquine, the first-line treatment used against P. vivax malaria, have been described in the Brazilian Amazon region. The aim of this study is to investigate a possible dispersion of chloroquine-resistant P. vivax isolates in French Guiana. The genotype, polymorphism and copy number variation, of the P. vivax multidrug resistance gene-1 (pvmdr1) have been previously associated with modification of the susceptibility to chloroquine.METHODS:The pvmdr1 gene polymorphism was evaluated by sequencing and copy number variation was assessed by real-time PCR, in P. vivax isolates obtained from 591 symptomatic patients from 1997 to 2013.RESULTS:The results reveal that 1.0% [95% CI 0.4-2.2] of French Guiana isolates carry the mutations Y976F and F1076L, and that the proportion of isolates with multiple copies of pvmdr1 has significantly decreased over time, from 71.3% (OR = 6.2 [95% CI 62.9-78.7], p < 0.0001) in 1997-2004 to 12.8% (OR = 0.03 [95% CI 9.4-16.9], p < 0.0001) in 2009-2013. A statistically significant relationship was found between Guf-A (harboring the single mutation T958M) and Sal-1 (wild type) alleles and pvmdr1 copy number.CONCLUSIONS:Few P. vivax isolates harboring chloroquine-resistant mutations in the pvmdr1 gene are circulating in French Guiana. However, the decrease in the prevalence of isolates carrying multiple copies of pvmdr1 might indicate that the P. vivax population in French Guiana is evolving towards a decreased susceptibility to chloroquine.
Url:
DOI: 10.1186/s12936-016-1595-9
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000190
- to stream Hal, to step Curation: 000190
- to stream Hal, to step Checkpoint: 000070
- to stream Main, to step Merge: 000D35
- to stream Main, to step Curation: 000D35
- to stream Main, to step Exploration: 000D35
- to stream France, to step Extraction: 000114
Links to Exploration step
Hal:pasteur-01400964Le document en format XML
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Région Antilles-Guyane</orgName> <desc> <address> <country key="GF"></country> </address> </desc> <listRelation> <relation active="#struct-413215" type="direct"></relation> <relation active="#struct-300193" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-413215" type="direct"><org type="institution" xml:id="struct-413215" status="INCOMING"> <orgName>WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</orgName> <desc> <address> <addrLine>Cayenne</addrLine> <country key="GF"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300193" type="direct"><org type="institution" xml:id="struct-300193" status="VALID"> <orgName>Institut Pasteur de la Guyane</orgName> <desc> <address> <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine> <country key="GF"></country> </address> <ref type="url">http://www.pasteur-cayenne.fr/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><wicri:noCountry>GF</wicri:noCountry></affiliation></author><author><name sortKey="Pelleau, Stephane" sort="Pelleau, Stephane" uniqKey="Pelleau S" first="Stéphane" last="Pelleau">Stéphane Pelleau</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-413216" status="VALID"> <orgName>Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane</orgName> <desc> <address> <country key="GF"></country> </address> </desc> <listRelation> <relation active="#struct-413215" type="direct"></relation> <relation active="#struct-300193" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-413215" type="direct"><org type="institution" xml:id="struct-413215" status="INCOMING"> <orgName>WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</orgName> <desc> <address> <addrLine>Cayenne</addrLine> <country key="GF"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300193" type="direct"><org type="institution" xml:id="struct-300193" status="VALID"> <orgName>Institut Pasteur de la Guyane</orgName> <desc> <address> <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine> <country key="GF"></country> </address> <ref type="url">http://www.pasteur-cayenne.fr/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><wicri:noCountry>GF</wicri:noCountry></affiliation></author><author><name sortKey="Volney, Beatrice" sort="Volney, Beatrice" uniqKey="Volney B" first="Béatrice" last="Volney">Béatrice Volney</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-413216" status="VALID"> <orgName>Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane</orgName> <desc> <address> <country key="GF"></country> </address> </desc> <listRelation> <relation active="#struct-413215" type="direct"></relation> <relation active="#struct-300193" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-413215" type="direct"><org type="institution" xml:id="struct-413215" status="INCOMING"> <orgName>WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</orgName> <desc> <address> <addrLine>Cayenne</addrLine> <country key="GF"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300193" type="direct"><org type="institution" xml:id="struct-300193" status="VALID"> <orgName>Institut Pasteur de la Guyane</orgName> <desc> <address> <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine> <country key="GF"></country> </address> <ref type="url">http://www.pasteur-cayenne.fr/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><wicri:noCountry>GF</wicri:noCountry></affiliation></author><author><name sortKey="Casteras, Jessica" sort="Casteras, Jessica" uniqKey="Casteras J" first="Jessica" last="Casteras">Jessica Casteras</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-413216" status="VALID"> <orgName>Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane</orgName> <desc> <address> <country key="GF"></country> </address> </desc> <listRelation> <relation active="#struct-413215" type="direct"></relation> <relation active="#struct-300193" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-413215" type="direct"><org type="institution" xml:id="struct-413215" status="INCOMING"> <orgName>WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</orgName> <desc> <address> <addrLine>Cayenne</addrLine> <country key="GF"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300193" type="direct"><org type="institution" xml:id="struct-300193" status="VALID"> <orgName>Institut Pasteur de la Guyane</orgName> <desc> <address> <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine> <country key="GF"></country> </address> <ref type="url">http://www.pasteur-cayenne.fr/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><wicri:noCountry>GF</wicri:noCountry></affiliation></author><author><name sortKey="Caro, Valerie" sort="Caro, Valerie" uniqKey="Caro V" first="Valérie" last="Caro">Valérie Caro</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-237998" status="VALID"> <idno type="RNSR">201321607J</idno> <orgName>Environnement et Risques infectieux - Environment and Infectious Risks</orgName> <orgName type="acronym">ERI</orgName> <desc> <address> <addrLine>Département Infection et Epidémiologie, 28, rue du Docteur Roux, 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/en/team/environment-and-infectious-risks/</ref> </desc> <listRelation> <relation active="#struct-300027" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300027" type="direct"><org type="institution" xml:id="struct-300027" status="VALID"> <idno type="IdRef">027936643</idno> <idno type="ISNI">0000 0001 2353 6535</idno> <orgName>Institut Pasteur [Paris]</orgName> <date type="start">1887-06-04</date> <desc> <address> <addrLine>25-28, rue du docteur Roux, 75724 Paris cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.pasteur.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Menard">Didier Menard</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-54022" status="VALID"> <orgName>Institut Pasteur du Cambodge</orgName> <desc> <address> <addrLine>BP 983 - 5 , Boulevard Monivong, Phnom Penh</addrLine> <country key="KH"></country> </address> <ref type="url">http://www.pasteur-kh.org/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-301247" type="direct"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>Cambodge</country></affiliation></author><author><name sortKey="Briolant, Sebastien" sort="Briolant, Sebastien" uniqKey="Briolant S" first="Sébastien" last="Briolant">Sébastien Briolant</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-507058" status="VALID"> <orgName>Institut de Recherche Biomédicale des Armées</orgName> <orgName type="acronym">IRBA</orgName> <desc> <address> <addrLine>Brétigny-sur-Orge</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.defense.gouv.fr/sante/notre-expertise/recherche-biomedicale/recherche-biomedicale</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Legrand, Eric" sort="Legrand, Eric" uniqKey="Legrand E" first="Eric" last="Legrand">Eric Legrand</name><affiliation><hal:affiliation type="laboratory" xml:id="struct-413216" status="VALID"> <orgName>Laboratoire de Parasitologie, Centre National de Référence du Paludisme - Région Antilles-Guyane</orgName> <desc> <address> <country key="GF"></country> </address> </desc> <listRelation> <relation active="#struct-413215" type="direct"></relation> <relation active="#struct-300193" type="direct"></relation> <relation active="#struct-301247" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-413215" type="direct"><org type="institution" xml:id="struct-413215" status="INCOMING"> <orgName>WHO Collaborating Center for Surveillance of Antimalarial Drug Resistance</orgName> <desc> <address> <addrLine>Cayenne</addrLine> <country key="GF"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300193" type="direct"><org type="institution" xml:id="struct-300193" status="VALID"> <orgName>Institut Pasteur de la Guyane</orgName> <desc> <address> <addrLine>23 Avenue Pasteur BP 6010 - 97306 Cayenne Cedex </addrLine> <country key="GF"></country> </address> <ref type="url">http://www.pasteur-cayenne.fr/</ref> </desc> <listRelation> <relation active="#struct-301247" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301247" type="indirect"><org type="regroupinstitution" xml:id="struct-301247" status="VALID"> <orgName>Réseau International des Instituts Pasteur</orgName> <orgName type="acronym">RIIP</orgName> <desc> <address> <addrLine>25, rue du Dr Roux 75724 Paris Cedex 15</addrLine> <country key="FR"></country> </address> <ref type="url">https://research.pasteur.fr/ip-network</ref> </desc> </org></tutelle></tutelles></hal:affiliation><wicri:noCountry>GF</wicri:noCountry></affiliation></author></analytic><idno type="DOI">10.1186/s12936-016-1595-9</idno><series><title level="j">Malaria Journal</title><idno type="ISSN">1475-2875</idno><imprint><date type="datePub">2016-11-08</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>BACKGROUND:Plasmodium vivax malaria is a major public health problem in French Guiana. Some cases of resistance to chloroquine, the first-line treatment used against P. vivax malaria, have been described in the Brazilian Amazon region. The aim of this study is to investigate a possible dispersion of chloroquine-resistant P. vivax isolates in French Guiana. The genotype, polymorphism and copy number variation, of the P. vivax multidrug resistance gene-1 (pvmdr1) have been previously associated with modification of the susceptibility to chloroquine.METHODS:The pvmdr1 gene polymorphism was evaluated by sequencing and copy number variation was assessed by real-time PCR, in P. vivax isolates obtained from 591 symptomatic patients from 1997 to 2013.RESULTS:The results reveal that 1.0% [95% CI 0.4-2.2] of French Guiana isolates carry the mutations Y976F and F1076L, and that the proportion of isolates with multiple copies of pvmdr1 has significantly decreased over time, from 71.3% (OR = 6.2 [95% CI 62.9-78.7], p < 0.0001) in 1997-2004 to 12.8% (OR = 0.03 [95% CI 9.4-16.9], p < 0.0001) in 2009-2013. A statistically significant relationship was found between Guf-A (harboring the single mutation T958M) and Sal-1 (wild type) alleles and pvmdr1 copy number.CONCLUSIONS:Few P. vivax isolates harboring chloroquine-resistant mutations in the pvmdr1 gene are circulating in French Guiana. However, the decrease in the prevalence of isolates carrying multiple copies of pvmdr1 might indicate that the P. vivax population in French Guiana is evolving towards a decreased susceptibility to chloroquine.</p> </div></front></TEI><affiliations><list><country><li>Belgique</li><li>Cambodge</li><li>France</li></country></list><tree><noCountry><name sortKey="Casteras, Jessica" sort="Casteras, Jessica" uniqKey="Casteras J" first="Jessica" last="Casteras">Jessica Casteras</name><name sortKey="Legrand, Eric" sort="Legrand, Eric" uniqKey="Legrand E" first="Eric" last="Legrand">Eric Legrand</name><name sortKey="Musset, Lise" sort="Musset, Lise" uniqKey="Musset L" first="Lise" last="Musset">Lise Musset</name><name sortKey="Pelleau, Stephane" sort="Pelleau, Stephane" uniqKey="Pelleau S" first="Stéphane" last="Pelleau">Stéphane Pelleau</name><name sortKey="Volney, Beatrice" sort="Volney, Beatrice" uniqKey="Volney B" first="Béatrice" last="Volney">Béatrice Volney</name></noCountry><country name="Belgique"><noRegion><name sortKey="Faway, Emilie" sort="Faway, Emilie" uniqKey="Faway E" first="Emilie" last="Faway">Emilie Faway</name></noRegion></country><country name="France"><noRegion><name sortKey="Caro, Valerie" sort="Caro, Valerie" uniqKey="Caro V" first="Valérie" last="Caro">Valérie Caro</name></noRegion><name sortKey="Briolant, Sebastien" sort="Briolant, Sebastien" uniqKey="Briolant S" first="Sébastien" last="Briolant">Sébastien Briolant</name></country><country name="Cambodge"><noRegion><name sortKey="Menard, Didier" sort="Menard, Didier" uniqKey="Menard D" first="Didier" last="Menard">Didier Menard</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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